反応 #474108

反応方程式

Naproxen

→

2-(6-Hydroxy-naphthalen-2-yl)-propionic acid

溶媒

HBr

反応条件

後処理

1. 1
   温度was refluxed for 10 Hours
2. 2
   workup.ADDITIONpoured onto ice water (3000 ml)
3. 3
   ろ過Crude 36 was filtered
4. 4
   その他dried (380 grams, 81%)

実験手順

A mixture of Naproxen (500 grams, 2.774 mmol) and 48% HBr (1500 ml) was refluxed for 10 Hours, poured onto ice water (3000 ml) and stirred for 30 minutes. Crude 36 was filtered, dried (380 grams, 81%) and used as such for next stage.

出典