反応 #4733

反応方程式

5-bromo-1,3,4-thiadiazole-2-amine

triethylamine

1-amino-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol

→

1-[(5-Amino-1,3,4-thiadiazol-2-yl)amino]-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol

溶媒

THF

反応条件

後処理

1. 1
   その他the mixture is reacted in a manner analogous to Example 51
2. 2
   その他The oil obtained
3. 3
   その他is purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95))

実験手順

0.54 g (3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amine and 0.45 ml of triethylamine are added to 0.8 g (3 mmol) of 1-amino-3-[3-(1-piperidinylmethyl)phenoxy]-2-propanol in 20 ml of THF and the mixture is reacted in a manner analogous to Example 51. The oil obtained is purified by column chromatography (silica gel; ammoniacal. Methanolchloroform solution (5+95)).

出典