反応 #4732

反応方程式

4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine

triethylamine

5-bromo-1,3,4-thiadiazole-2-amin

→

N-[4-[3-(1-piperidinylmethyl)phenoxy]-2-butenyl]-1,3,4-thiadiazole-2,5-diamine

溶媒

THF

反応条件

後処理

1. 1
   ろ過Solid triethylammonium bromide is filtered off
2. 2
   濃縮the filtrate is concentrated by evaporation
3. 3
   その他the oily residue is purified by preparative layer chromatography

実験手順

0.6 g (2.3 mmol) of 4-[3-(1-piperidinylmethyl)phenoxy]2-butene-1-amine, 0.35 ml of triethylamine and 0.42 g (2.3 mmol) of 5-bromo-1,3,4-thiadiazole-2-amin are heated under reflux in 20 ml of THF for 3 hours. Solid triethylammonium bromide is filtered off, the filtrate is concentrated by evaporation and the oily residue is purified by preparative layer chromatography.

出典