反応 #4724

反応方程式

Hydrogen peroxide

N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

溶媒

ethanol

反応条件

後処理

1. 1
   温度the reaction mixture is briefly heated to boiling
2. 2
   ろ過The sulphur which separates is filtered off hot with the aid of active charcoal
3. 3
   濃縮the filtrate is concentrated by evaporation
4. 4
   その他purified by preparative layer chromatography

実験手順

2 ml of 30% Hydrogen peroxide are added to 1.58 g (4 mmol) of N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide in 30 ml of ethanol and the reaction mixture is briefly heated to boiling. The sulphur which separates is filtered off hot with the aid of active charcoal and the filtrate is concentrated by evaporation and purified by preparative layer chromatography.

出典