反応 #4722

反応方程式

triethylamine

phenyl isocyanide dichloride

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide

→

N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-oxadiazole-2,5-diamine

溶媒

THF

反応条件

後処理

1. 1
   ろ過Solid triethylammonium chloride is filtered off
2. 2
   濃縮the filtrate is concentrated by evaporation under vacuum
3. 3
   その他the solid residue is recrystallised from ethanol

実験手順

1.4 ml (10 mmol) of triethylamine and 0.7 ml (5 mmol) of phenyl isocyanide dichloride are added to 1.5 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-hydrazine carboxamide in 30 ml of THF and the mixture is stirred at room temperature until the reaction is quantitative. Solid triethylammonium chloride is filtered off, the filtrate is concentrated by evaporation under vacuum, and the solid residue is recrystallised from ethanol. The analytical values are summarized in Table II.

出典