反応 #472120

ord-72988a8d24ca4560921a3e352fe52cf0

反応方程式

CC(C)(C)OC(=O)NC(C(=O)c1ccc(O)cc1)c1ccc(Cl)c(Cl)c1
rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
OC1CCSCC1
tetrahydro-2H-thiopyran-4-ol
→
CC(C)(C)OC(=O)NC(C(=O)c1ccc(OC2CCSCC2)cc1)c1ccc(Cl)c(Cl)c1
title compound
CC(C)(C)OC(=O)NC(C(=O)c1ccc(OC2CCSCC2)cc1)c1ccc(Cl)c(Cl)c1
rac-[1-(3,4-Dichloro-phenyl)-2-oxo-2-[4-(tetrahydro-thiopyran-4-yloxy)-phenyl]-ethyl]-carbamic acid tert-butyl ester

反応物

CC(C)(C)OC(=O)NC(C(=O)c1ccc(O)cc1)c1ccc(Cl)c(Cl)c1
rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
OC1CCSCC1
tetrahydro-2H-thiopyran-4-ol

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared from rac-[1-(3,4-dichloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and tetrahydro-2H-thiopyran-4-ol in analogy to Example 9c): MS (ISP): 496.2 and 498.1 (M+H)+, 396.1 and 397.9 ((M-Boc)+H)+ (100%).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08367838B2uspto-grants-2013_02