反応 #472107

反応方程式

rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester

Intermediate 9

rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester

rac-2-(4-bromo-3-fluoro-phenoxymethyl)-oxetane

Intermediate 27

rac-2-(4-bromo-3-fluoro-phenoxymethyl)-oxetane

→

title compound

rac-[1-(3,4-Dichloro-phenyl)-2-[2-fluoro-4-(oxetan-2-yl-methoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

反応条件

実験手順

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and rac-2-(4-bromo-3-fluoro-phenoxymethyl)-oxetane (Intermediate 27) in analogy to Example 1a): colorless gum.

出典