反応 #47146

反応方程式

HCl

4-chloroaniline

pivaloyl chloride

→

title compound

N-(4-Chloro-phenyl)-2,2-dimethyl-propionamide

溶媒

pyridine

反応条件

後処理

1. 1
   workup.ADDITIONThe mixture was poured
2. 2
   ろ過the solids were collected by vacuum filtration
3. 3
   洗浄washed well with H2O
4. 4
   その他dried in vacuo

実験手順

To a solution of 4-chloroaniline (5.0 g, 39.2 mmol) in 25 mL pyridine was added 5.3 mL (43.1 mmol) of pivaloyl chloride and the reaction mixture stirred overnight at room temperature. The mixture was poured into vigorously stirring 6M HCl, and the solids were collected by vacuum filtration, washed well with H2O, and dried in vacuo to yield the title compound. 1H NMR (CDCl3) δ 7.47 (d, J=9.2 Hz, 2H) 7.30 (s, 1H) 7.27 (d, J=8.8 Hz, 2H) 1.32 (s, 9H) MS (ES) m/z=212.1

出典