反応 #471024

反応方程式

azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone

1-(5-(2-bromoethyl)indolin-1-yl)ethanone

potassium carbonate

→

title compound

1-(5-(2-(4-(2-(Azetidine-1-carbonyl)benzofuran-7-yl)piperazin-1-yl)ethyl)indolin-1-yl)ethanone

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度The mixture was cooled
2. 2
   その他the solvent was removed in vacuo
3. 3
   その他The product was purified by flash chromatography (SiO2; DCM/MeOH; gradient 0-5%)

実験手順

The reaction mixture of azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone (0.070 g, 0.25 mmol) (Example 45c), 1-(5-(2-bromoethyl)indolin-1-yl)ethanone (0.099 g, 0.37 mmol) and potassium carbonate (0.068 g, 0.49 mmol) in acetonitrile (1 mL) was heated by microwave irradiation at 120° C. for 15 min. The mixture was cooled and the solvent was removed in vacuo. The product was purified by flash chromatography (SiO2; DCM/MeOH; gradient 0-5%) to give the title compound. Yield: 0.056 g (48%).

出典