反応 #471003

反応方程式

Trifluoroacetic acid

tert-butyl 4-(2-(1-acetylindolin-5-yl)ethyl)piperazine-1-carboxylate

→

product

収率 101.8%

1-(5-(2-(piperazin-1-yl)ethyl)indolin-1-yl)ethanone

収率 101.8%

溶媒

DCM

反応条件

後処理

1. 1
   その他The mixture was evaporated
2. 2
   抽出was extracted with DCM (3×)
3. 3
   乾燥dried (Na2SO4)
4. 4
   ろ過filtered
5. 5
   その他evaporated

実験手順

Trifluoroacetic acid (4.08 mL, 53.08 mmol) was added to a solution of tert-butyl 4-(2-(1-acetylindolin-5-yl)ethyl)piperazine-1-carboxylate (0.793 g, 2.12 mmol) in dry DCM and the reaction was stirred at room temperature for 60 min. The mixture was evaporated and the crude mixture was made basic with 10% NaOH aq. The aq phase was extracted with DCM (3×), dried (Na2SO4), filtered and evaporated to give 0.590 g of the product. This product was taken to the next step assuming quantitative yield without further purification. MS (ES+) m/z 274.2 (M+H)+.

出典