反応 #47088

反応方程式

cyclohexanol

ethyl diazoacetate

→

product 407

Cyclohexyloxyacetic acid ethyl ester

溶媒

Et2O

dichloromethane

反応条件

後処理

1. 1
   ろ過filtered through Celite
2. 2
   その他the filtrate is evaporated
3. 3
   workup.DISTILLATIONdistilled at 150° C.

実験手順

To a solution of cyclohexanol (1.0 g, 0.95 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (44 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is diluted with Et2O, filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 150° C. to give 1.57 g of the product 407. 1H NMR (CDCl3) δ 4.23 (q, 2H), 4.10 (s, 2H), 3.33 (m, 1H), 1.93 (m, 2H), 1.74 (m, 2H), 1.54 (m, 1H), 1.4-1.1 (m, 8H)

出典