反応 #47085

反応方程式

Et2O

thiophenol

potassium carbonate

ethyl bromoacetate

→

product 400

収率 89.8%

(Phenylthio)acetic acid ethyl ester

収率 89.8%

溶媒

DMF

反応条件

後処理

1. 1
   洗浄the mixture is washed with water, brine
2. 2
   乾燥dried (MgSO4)
3. 3
   ろ過filtered
4. 4
   その他The filtrate is evaporated
5. 5
   workup.DISTILLATIONdistilled (130-140° C.)

実験手順

To a solution of thiophenol (1 mL, 9.7 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.71 g of the product 400. 1H NMR (CDCl3) δ 7.41 (d, 2H), 7.33-7.2 (m, 4H), 4.16 (q, 2H), 3.63 (s, 2H), 1.22 (t, 3H); MS: m/z 196 (M++1).

出典