反応 #47077

反応方程式

chloroacetonitrile

2-fluorophenol

potassium carbonate

→

product 384

収率 97.4%

(2-Fluorophenoxy)acetonitrile

収率 97.4%

溶媒

EtOAc

DMF

反応条件

後処理

1. 1
   温度The reaction mixture is cooled to RT
2. 2
   洗浄washed with water, brine
3. 3
   乾燥dried (MgSO4)
4. 4
   ろ過filtered
5. 5
   その他The filtrate is evaporated
6. 6
   その他the residue purified by chromatography on silica gel
7. 7
   洗浄elution with dichloromethane

実験手順

To a solution of 2-fluorophenol (560 mg, 5.0 mmol) in DMF (10 mL) is added potassium carbonate (828 mg, 6.0 mmol) followed by chloroacetonitrile (0.315 mL, 50.0 mmol). The reaction mixture is stirred and heated at 50° C. for 14 h. The reaction mixture is cooled to RT, diluted with EtOAc, and washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue purified by chromatography on silica gel; elution with dichloromethane gives 736 mg of the product 384.

出典