反応 #47069

反応方程式

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2,4-dimethylbenzyl chloride

→

product 240

収率 55.1%

2-[(2,4-Dimethylbenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

収率 55.1%

溶媒

EtOH

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   ろ過The insoluble material is filtered

実験手順

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2,4-dimethylbenzyl chloride (243 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 177 mg of the product 240. 1H NMR (DMSO-d6) δ 11.18 (s, 2 H), 7.20-6.80 (m, 13 H), 5.80 (s, 2 H), 4.88 (s, 2 H), 2.41 (s, 3H), 2.30 (s, 3 H); MS: m/z 373 (M++1).

出典