反応 #47065

反応方程式

intermediate 25

cis-4,5-Diphenylimidazolidine-2-thione

2,3,5,6-tetramethylbenzyl chloride

→

product 236

収率 51.5%

2-[(2,3,5,6-Tetramethylbenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole hydrochloride

収率 51.5%

溶媒

EtOH

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   ろ過The insoluble material is filtered

実験手順

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2,3,5,6-tetramethylbenzyl chloride (287 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 177 mg of the product 236. 1H NMR (DMSO-d6) δ 11.33 (s, 2 H), 7.25-6.95 (m, 11 H), 5.86 (s, 2 H), 4.84 (s, 2 H), 2.35 (s, 6 H), 2.21 (s, 6 H); MS: m/z 401 (M++1).

出典