反応 #470392

反応方程式

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

収率 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

収率 47.9%

溶媒

water

反応条件

後処理

1. 1
   温度After cooled to room temperature
2. 2
   抽出The mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   その他The solvent was evaporated
4. 4
   その他the residue was purified by column chromatography

実験手順

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

出典