反応 #470387

反応方程式

N1-phenylbenzene-1,2-diamine

benzaldehyde

→

desired product

収率 37.0%

1,2-diphenyl-1H-benzo[d]imidazole

収率 37.0%

溶媒

methoxylethanol

反応条件

後処理

1. 1
   温度The mixture was heated up
2. 2
   温度to reflux for 48 hours
3. 3
   その他the solvent was evaporated
4. 4
   その他The residue was purified by column chromatography

実験手順

N1-phenylbenzene-1,2-diamine (4.15 g, 22 mmol) and benzaldehyde (2.1 g, 20 mmol) were mixed with methoxylethanol (60 ml) in a three-neck flask. The mixture was heated up to reflux for 48 hours. After cooled to room temperature, the solvent was evaporated. The residue was purified by column chromatography using dichloromethane to 5% of ethyl acetate in dichloromethane as eluent. 2 g of desired product was obtained.

出典