反応 #470362

反応方程式

ethyldimethylamine

chloromethyl methyl ether

→

N-ethyl-N-methoxymethyl-N,N-dimethylammonium chloride

溶媒

acetone

反応条件

後処理

1. 1
   その他to terminate
2. 2
   その他the reaction
3. 3
   温度The reaction mixture was cooled to 5° C.
4. 4
   ろ過the resulting solids were filtered off in nitrogen
5. 5
   洗浄The filter cake was washed with 150 g of acetone
6. 6
   その他dried in a vacuum

実験手順

A 47.50 g quantity of ethyldimethylamine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 300 g of dehydrated acetone (reagent, Wako Pure Chemical Ind. Ltd.), followed by replacement with nitrogen. To the solution was added dropwise 52.30 g of chloromethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd. as purified by distillation) at 5° C. over a period of 1 hour. The mixture was thereafter stirred at a temperature of not higher than 15° C. for 5 hours to terminate the reaction. The reaction mixture was cooled to 5° C., and the resulting solids were filtered off in nitrogen. The filter cake was washed with 150 g of acetone, and thereafter dried in a vacuum, giving 85.90 g of N-ethyl-N-methoxymethyl-N,N-dimethylammonium chloride (white solid).

出典