反応 #470359

反応方程式

N-methylpyrrolidine

Chloromethyl methyl ether

→

desired product

N-Methyl-N-Methoxymethylpyrrolidinium Chloride

溶媒

toluene

反応条件

後処理

1. 1
   温度gradually heated to a higher temperature
2. 2
   workup.STIRRINGstirred at room temperature for 10 hours
3. 3
   その他the reaction
4. 4
   ろ過The reaction mixture was filtered
5. 5
   洗浄the resulting solid product was washed with 150 g of toluene and 150 g of acetone
6. 6
   その他The washed product was dried in a vacuum

実験手順

A 30.0 g quantity of N-methylpyrrolidine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 120 g of toluene, followed by replacement with nitrogen. Chloromethyl methyl ether (31.2 g, reagent, product of Tokyo Kasei Co., Ltd.) was added dropwise to the solution at 5° C. over a period of 1 hour. The mixture was stirred at 5° C. for 1 hour, then gradually heated to a higher temperature, and stirred at room temperature for 10 hours to complete the reaction. The reaction mixture was filtered, and the resulting solid product was washed with 150 g of toluene and 150 g of acetone. The washed product was dried in a vacuum to obtain 53.7 g of the desired product (white solid).

出典