反応 #470273

反応方程式

triphenylphosphine

diethyl azodicarboxylate

hydrazoic acid

benzene

resultant compound

4-(Hydroxymethyl)-2-phenylbenzoyl methionine methyl ester

→

title product

4-(Azidomethyl)-2-phenylbenzoyl methionine methyl ester

溶媒

tetrahydrofuran

THF

反応条件

後処理

1. 1
   その他evaporated
2. 2
   その他chromatographed on silica gel

実験手順

To triphenylphosphine (1.0 equivalent) in tetrahydrofuran (THF) at −78° C. is added diethyl azodicarboxylate (1.0 equivalent) in THF. To this mixture is added a solution of hydrazoic acid in benzene (2.0 equivalents) and then the resultant compound from Example 16D (1.0 equivalent). After one hour the mixture was warmed to room temperature, stirred until the reaction is judged complete by TLC analysis, evaporated and chromatographed on silica gel to afford the title product.

出典