反応 #469754

反応方程式

4-methyl-2-nitroaniline

(E)-4-methoxycinnamoyl chloride

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

hydrogen chloride

→

titled compound

(E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   濃縮Concentration and recrystallization from ethyl acetate/ethanol

実験手順

Free base of the titled compound was prepared from 4-methyl-2-nitroaniline and (E)-4-methoxycinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.

出典