反応 #469717

反応方程式

oxalic acid

N-(2-pyridyl)-o-phenylenediamine

3,4-dimethoxycinnamoyl chloride

(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

→

titled compound

(E)-3,4-Dimethoxystyryl-1-(2-pyridyl)-1H-benzimidazole oxalate

溶媒

ethyl acetate

反応条件

後処理

1. 1
   濃縮Concentration and recrystallization from ethyl acetate/n-hexane

実験手順

Free base of the titled compound was prepared from N-(2-pyridyl)-o-phenylenediamine and 3,4-dimethoxycinnamoyl chloride (Ramamurthy, B.; Sugumaran, M. Synthesis, 1987, 523) according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.

出典