反応 #46943

反応方程式

3-Fluoro-4-morpholinyl aniline

R-epichlorohydrin

→

N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline

収率 99.3%

溶媒

isopropyl alcohol

反応条件

後処理

1. 1
   workup.ADDITIONis added
2. 2
   温度heated for 16 hours
3. 3
   温度at reflux temperature
4. 4
   workup.DISTILLATIONThe solvent is distilled

実験手順

3-Fluoro-4-morpholinyl aniline (39 g) is mixed with R-epichlorohydrin (18.5 g), isopropyl alcohol (200 ml) is added and heated for 16 hours at reflux temperature. The solvent is distilled to give 57 gm of N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline.

出典