反応 #468632

反応方程式

pentafluoropyridine

sodium methoxide

→

4-methoxy-2,3,5,6-tetrafluoropyridine

溶媒

反応条件

後処理

1. 1
   洗浄the reaction was washed with water
2. 2
   乾燥dried (MgSO4)
3. 3
   その他the solvent was removed in vacuo

実験手順

To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.

出典