反応 #468538

反応方程式

6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid

(R)-(−)-2-amino-3-methyl-1-butanol

→

desired compound

収率 73.0%

5-[N-[(1R)-2-hydroxy-1-isopropylethyl]carbamoyl]-2-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]pyridine

収率 73.0%

反応条件

後処理

1. 1
   その他By the same procedure as described in the example 1, synthesis
2. 2
   その他Then, the product was recrystallized with acetone and hexane

実験手順

By the same procedure as described in the example 1, synthesis was carried out starting with 6-[1-[3-(isopropylamino)-2-pyridyl]piperazin-4-yl-carbonyl]nicotinic acid and using (R)-(−)-2-amino-3-methyl-1-butanol. Then, the product was recrystallized with acetone and hexane to give a desired compound.

出典