反応 #46788

反応方程式

[1-(2-Chloro-pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester

→

product

(1-Pyrimidin-4-yl-piperidin-4-yl)-carbamic acid tert-butyl ester

溶媒

ethanol

acetic acid

反応条件

後処理

1. 1
   その他the mixture purged with argon for 10 min
2. 2
   workup.ADDITIONAfter addition of 10 mL ethyl acetate the reaction mixture
3. 3
   ろ過was filtered through a pad of celite
4. 4
   その他The solvent was evaporated under reduced pressure

実験手順

To a solution of 395 mg [1-(2-Chloro-pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester in 10 mL ethanol and 0.3 mL acetic acid, 20 mg Pd/C (10%) were added and the mixture purged with argon for 10 min. Then the mixture was stirred under a hydrogen atmosphere for 5 h at RT. After addition of 10 mL ethyl acetate the reaction mixture was filtered through a pad of celite. The solvent was evaporated under reduced pressure and the residue codistilled twice with toluene to give the product as a white solid. Yield: 468 mg.

出典