反応 #46768

反応方程式

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

収率 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

収率 98.3%

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   その他A 100 mL round bottom flask equipped with a stir bar
2. 2
   洗浄washed with water (3×100 mL)
3. 3
   乾燥Organic layer was dried over anhydrous sodium sulfate
4. 4
   濃縮concentrated under reduced pressure

実験手順

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

出典