反応 #46754

反応方程式

intermediate 15

tert-butyl 3-(3,4-difluorophenyl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate

dihydro-2H-pyran-3(4H)-one

5-chloro-2-fluorobenzoyl chloride

→

Intermediate 16C

3-(5-chloro-2-fluorophenyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole

反応条件

実験手順

Intermediate 16C was prepared according to the procedure for the synthesis of intermediate 15 by replacing 1-Boc-4-piperidone with dihydro-2H-pyran-3(4H)-one, and replacing 3,4-difluorobenzoyl chloride with 5-chloro-2-fluorobenzoyl chloride. LCMS (+ESI) m/z=253 [M+H]+.

出典