反応 #46740

反応方程式

3-Imidazol-1-yl-propylamine

2-Hydroxy-5-methyl-benzaldehyde

Trimethylsilylazide

1-Chloro-4-isocyanomethyl-benzene

→

2-[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

溶媒

methanol

反応条件

後処理

1. 1
   その他After evaporation of the solvent the residue
2. 2
   その他was purified with chromatographic methods

実験手順

3-Imidazol-1-yl-propylamine (1 mmol) and 2-Hydroxy-5-methyl-benzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Chloro-4-isocyanomethyl-benzene (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

出典