反応 #4670

反応方程式

methyl iodide

compound 6a

1-Methyl-3-{N-[β-(3,4-dihydroxyphenyl)-ethyl]}carbamoylpyridinium iodide

3-methoxytyramine

→

1-Methyl-3-{N-[β-(4-hydroxy-3-methoxyphenyl)ethyl]}carbamoylpyridinium iodide

反応条件

後処理

1. 1
   その他Crystallization from methanol
2. 2
   その他gave a yellow crystalline compound, m.p. 192°-194° C. with overall yield of 84%

実験手順

N-nicotinoyl-3-methoxytyramine was prepared by following the procedure used for the preparation of compound 7. The isolated crude amide was quaternized directly with methyl iodide following the method used for the preparation of compound 6a. Crystallization from methanol gave a yellow crystalline compound, m.p. 192°-194° C. with overall yield of 84%, calculated on the basis of 3-methoxytyramine starting material. NMR (D2O) closely similar to that of 6a except for the singlet at δ 3.66 for OCH3.

出典