反応 #46687

反応方程式

sodium hydrogencarbonate

N-Methylmorpholine

isobutyl chlorocarbonate

Bromoacetic acid

2-(1-adamantyl)-N-pentylethylamine hydrochloride

→

2-bromoacetic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide

溶媒

ethyl acetate

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   workup.STIRRINGThe whole was stirred at 0° C. for 1.5 hours
2. 2
   洗浄The ethyl acetate layer was washed with water (70 ml)
3. 3
   乾燥a saturated aqueous sodium chloride solution (70 ml) successively, dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure

実験手順

Bromoacetic acid (0.50 g, 3.6 mmol) was dissolved in anhydrous tetrahydrofuran (20 ml), and the solution was stirred at −15° C. under a nitrogen atmosphere. N-Methylmorpholine (0.40 ml, 3.6 mmol) and isobutyl chlorocarbonate (0.45 ml, 3.5 mmol) were added to the solution. Then a solution of a free base of 2-(1-adamantyl)-N-pentylethylamine hydrochloride (Intermediate No. 1-1, 1.0 g, 3.5 mmol) in anhydrous tetrahydrofuran (20 ml) was added dropwise to the mixture. The whole was stirred at 0° C. for 1.5 hours, then a saturated aqueous sodium hydrogencarbonate solution (70 ml) and ethyl acetate (70 ml) were added to the reaction mixture to distribute it. The ethyl acetate layer was washed with water (70 ml) and a saturated aqueous sodium chloride solution (70 ml) successively, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 2-bromoacetic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide (1.3 g, quantitatively) as an oily matter.

出典