反応 #46665

反応方程式

hydrochloric acid

diethyl 2-methyl-2-(4-pyridylmethyl)malonate

→

2-methyl-3-(4-pyridyl)propionic acid

収率 100.3%

反応条件

後処理

1. 1
   温度the mixture was refluxed overnight
2. 2
   洗浄washed with hexane (100 ml)
3. 3
   その他to remove sodium hydride oil
4. 4
   濃縮concentrated under reduced pressure
5. 5
   ろ過The resulting crystals were filtered off with ethyl acetate

実験手順

Next, 6 N hydrochloric acid (96.8 ml, 581 mmol) was added to diethyl 2-methyl-2-(4-pyridylmethyl)malonate (17.2 g, 64.6 mmol), and the mixture was refluxed overnight. The reaction mixture was allowed to stand, then washed with hexane (100 ml) to remove sodium hydride oil contained in diethyl 2-methyl-2-(4-pyridylmethyl)malonate and concentrated under reduced pressure. The resulting crystals were filtered off with ethyl acetate to give 2-methyl-3-(4-pyridyl)propionic acid (10.7 g, 82%) as pale pink crystals.

出典