反応 #4665

反応方程式

2,5-difluoro-4-aminobenzoic acid

dimethoxytetrahydrofuran

water

→

solid

収率 79.2%

2,5-difluoro-4-(pyrrol-1-yl)benzoic acid

収率 79.2%

溶媒

acetic acid

反応条件

後処理

1. 1
   温度The mixture is heated at the boil for 10 minutes
2. 2
   workup.WAITthe resulting mixture is left
3. 3
   温度to cool
4. 4
   その他The precipitate formed
5. 5
   ろ過is filtered off
6. 6
   洗浄washed with water

実験手順

5.2 grams (0.03 mol) of 2,5-difluoro-4-aminobenzoic acid, melting at 250°-3°, are dissolved in 60 ml of glacial acetic acid, and 4 grams (0.03 mol) of dimethoxytetrahydrofuran are added. The mixture is heated at the boil for 10 minutes, 20 ml of water are added and the resulting mixture is left to cool. The precipitate formed is filtered off and washed with water to give 5.3 grams of a solid melting at 196°-8° C.

出典