反応 #465936

反応方程式

1-Phenyl-2-methoxycarbonyl-4-acetoxy-6,7-dimethoxynaphthalene

sodium hydroxide

→

1-phenyl-4-hydroxy-6,7-dimethoxy-2-naphthoic acid

収率 100.7%

溶媒

methanol

反応条件

後処理

1. 1
   温度heated
2. 2
   温度to reflux for 3 hours
3. 3
   その他A white precipitate formed
4. 4
   ろ過was collected by vacuum filtration
5. 5
   洗浄washed with water
6. 6
   その他was air-dried
7. 7
   その他Recrystallization from ethanol (95 weight percent)

実験手順

1-Phenyl-2-methoxycarbonyl-4-acetoxy-6,7-dimethoxynaphthalene (66.4 grams) from Step 3, 500 mL of a 10 weight percent aqueous sodium hydroxide solution and 50 mL of methanol were added to a reaction flask and heated to reflux for 3 hours and then cooled to room temperature. The reaction mixture was poured onto an aqueous solution of 4N hydrochloric acid/ice mixture (˜400 mL). A white precipitate formed and was collected by vacuum filtration, washed with water and was air-dried. Recrystallization from ethanol (95 weight percent) gave 57 grams of 1-phenyl-4-hydroxy-6,7-dimethoxy-2-naphthoic acid.

出典