反応 #4658

反応方程式

ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate

potassium carbonate

cyclopropylmethyl bromide

→

solid

収率 62.3%

ethyl 6-fluoro-7-(pyrrol-1-yl)-1-cyclopropylmethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate

収率 62.3%

溶媒

dimethlformamide

反応条件

後処理

1. 1
   workup.WAITleft
2. 2
   温度to cool
3. 3
   workup.WAITleft
4. 4
   温度to cool
5. 5
   その他the precipitate formed
6. 6
   ろ過is filtered off
7. 7
   洗浄washed with water
8. 8
   その他recrystallized from ethanol

実験手順

A mixture of 3.6 g (0.012 mol) of ethyl 6-fluoro-7-(pyrrol-1-yl)-4-hydroxyquinoline-3-carboxylate and 4.15 g (0.03 mol) of potassium carbonate in 30 ml of dimethlformamide is heated for 30 minutes at 80° C. and left to cool, 8 g (0.06 mol) of cyclopropylmethyl bromide are added, the mixture is kept for 12 hours at 90° C. and left to cool, 80 ml of a water/ice mixture are added and the precipitate formed is filtered off, washed with water and recrystallized from ethanol to give 2.65 g of a solid melting at 125°-127° C.

出典