反応 #4653

反応方程式

4-(2-hydroxyethoxy)phenol

epichlorohydrin

potassium carbonate

→

1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene

反応条件

後処理

1. 1
   温度to reflux temperature
2. 2
   ろ過The reaction mixture is filtered
3. 3
   濃縮the filtrate is concentrated by evaporation under reduced pressure
4. 4
   その他is recrystallised from isopropanol

実験手順

With stirring, 13 g of crude 4-(2-hydroxyethoxy)phenol, 35 m of epichlorohydrin and 23.5 g of potassium carbonate are heated for 11/2 hours to reflux temperature. The reaction mixture is filtered and the filtrate is concentrated by evaporation under reduced pressure. The residual oil gradually congeals to a crystalline solid, which is recrystallised from isopropanol, affording 1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene with a melting point of 65°-67° C. Working up of the mother liquor yields further crystalline product.

出典