反応 #46478

反応方程式

bromine

acetophenone

Intermediate A

acetophenone

Bromine

acetophenone

chloroform

→

Intermediate B

2-bromoacetophenone

溶媒

diethyl ether

methylenechloride

diethyl ether

methylene chloride

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   その他Solvent was removed under reduced pressure

実験手順

The appropriate acetophenone (Intermediate A) was dissolved in diethyl ether, methylene chloride, or chloroform, and cooled to 0° C. Bromine (1.1 equiv) was dissolved in either methylenechloride or diethyl ether and added to the solution of acetophenone via a dropping funnel. After the addition of bromine was complete 2 drops of acetic acid were added and the solution was warmed to room temperature. Solvent was removed under reduced pressure to provide crude 2-bromoacetophenone (Intermediate B) which was generally used without further purification.

出典