反応 #4636

反応方程式

2,6-dihydroxybenzamide

potassium carbonate

1,2-dibromoethane

→

6-(2-Bromoethoxy)salicylamide

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度is refluxed
2. 2
   ろ過The reaction mixture is filtered
3. 3
   温度whilst still warm
4. 4
   濃縮the filtrate concentrated by evaporation
5. 5
   その他the residue recrystallised from a little methanol

実験手順

A mixture of 23.0 g of 2,6-dihydroxybenzamide, 20.7 g of potassium carbonate and 28.2 g of 1,2-dibromoethane is refluxed, whilst stirring, for 2-3 hours in 300 ml of acetonitrile. The reaction mixture is filtered whilst still warm, the filtrate concentrated by evaporation and the residue recrystallised from a little methanol. 6-(2-Bromoethoxy)salicylamide having a melting point of 120°-121° is obtained.

出典