反応 #463502

反応方程式

9-methoxy-5-methyl-2-(2-methylphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline

chloroform

→

title compound

収率 61.6%

9-Methoxy-5-methyl-2-(2-methylphenyl)imidazo[2,1-a]isoquinoline

収率 61.6%

溶媒

decalin

反応条件

後処理

1. 1
   温度the mixture was refluxed for 6 hours
2. 2
   温度After being cooled
3. 3
   ろ過the mixture was filtered
4. 4
   その他the filtrate was evaporated in vacuo
5. 5
   その他The resultant residue was crystallized from a mixture of hexane and ethyl acetate(6:1)

実験手順

To a solution of 4.9 g of 9-methoxy-5-methyl-2-(2-methylphenyl)-5,6-dihydroimidazo[2,1-a]isoquinoline in 30 ml of decalin was added 0.97 g of palladium on activated carbon (Pd 10%) and the mixture was refluxed for 6 hours. After being cooled and an addition of 200 ml of chloroform, the mixture was filtered and the filtrate was evaporated in vacuo. The resultant residue was crystallized from a mixture of hexane and ethyl acetate(6:1) to give 3.0 g of the title compound.

出典