反応 #46340

反応方程式

4-Methylsulfonylpyridine

hydrogen peroxide

ammonia

sodium hydrogen sulfite

4-methylsulfanyl-pyridine

→

4-methyl-sulfonylpyridine

溶媒

water

acetic acid

反応条件

後処理

1. 1
   その他The crude oil obtained
2. 2
   その他is crystallized with 10 cm3 of diisopropyl ether
3. 3
   ろ過the crystals are filtered
4. 4
   その他dried under reduced pressure (2.7 kPa)

実験手順

4-Methylsulfonylpyridine may be prepared by carrying out the procedure as described in Example 20, starting with 14 g of sodium tungstate, 4 cm3 of water, 0.05 cm3 of 100% acetic acid, 3.3 g of 4-methylsulfanyl-pyridine, 6.5 cm3 of 30% hydrogen peroxide and then 0.25 cm3 of 32% aqueous ammonia and 1 cm3 of 37.5% aqueous solution of sodium hydrogen sulfite. The crude oil obtained is crystallized with 10 cm3 of diisopropyl ether, the crystals are filtered, drained and dried under reduced pressure (2.7 kPa). 2.6 g of 4-methyl-sulfonylpyridine are obtained in the form of white crystals.

出典