反応 #463208

反応方程式

potassium hydroxide

tetrafluorophthalic anhydride

4-fluorobenzyl alcohol

→

(4-fluorobenzyloxy) trifluorobenzoic acid

収率 47.0%

溶媒

water

反応条件

後処理

1. 1
   抽出to the extraction steps

実験手順

8.4 g (0.15 mol) of potassium hydroxide are dissolved in 30 g of water, and 6.6 g (30mmol) of tetrafluorophthalic anhydride and 30 g (0.238 mol) of 4-fluorobenzyl alcohol are added. The mixture is heated at 100° C. for 12 hours after which the procedure as described in Example 2 is followed. It is advantageous not to allow the pH to fall below 3 prior to the extraction steps. This method gives 4.2 g (14 mmol, corresponding to 47%) of (4-fluorobenzyloxy) trifluorobenzoic acid (purity 80-85%).

出典