反応 #4632

反応方程式

2-benzyloxybenzyl isocyanate

ethanolamine

→

N-(2-hydroxyethyl)-N'-(2-benzyloxybenzyl)urea

溶媒

methylene chloride

methylene chloride

反応条件

後処理

1. 1
   洗浄After 2 hours the reaction solution is washed three times with 200 ml of water each time
2. 2
   その他dried
3. 3
   workup.DISTILLATIONMethylene chloride is distilled off
4. 4
   その他the residue is recrystallised from isopropanol

実験手順

A solution of 73.6 g of crude 2-benzyloxybenzyl isocyanate in 120 ml of methylene chloride is added dropwise in the course of 50 minutes in a solution of 36.8 ml of ethanolamine in 370 ml of methylene chloride. The reaction is slightly exothermic. After 2 hours the reaction solution is washed three times with 200 ml of water each time and dried using sodium sulphate. Methylene chloride is distilled off and the residue is recrystallised from isopropanol. The resulting product melts at 92°-94°.

出典