反応 #46295

反応方程式

4-hydroxybutylamine

tert-butyl bromoacetate

→

tert-Butyl[(4-hydroxybutyl)amino]acetate

溶媒

diethyl ether

diethyl ether

反応条件

後処理

1. 1
   洗浄The product mixture was washed successively with aqueous NaHCO3, water, and brine
2. 2
   抽出The organic extract
3. 3
   乾燥was dried over anhydrous sodium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated under vacuum
6. 6
   その他This intermediate was used in the following reaction without further purification

実験手順

To a cold (0° C.) solution of 4-hydroxybutylamine (9.1 g, 101.8 mmol) in diethyl ether (100 mL), a solution of tert-butyl bromoacetate (7.4 g, 49.3 mmol) in diethyl ether (25 mL) was added dropwise over a period of 2 hours. The reaction mixture was allowed to warm up slowly to room temperature and stirred at the temperature overnight. The product mixture was washed successively with aqueous NaHCO3, water, and brine. The organic extract was dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum. This intermediate was used in the following reaction without further purification.

出典