反応 #46180

反応方程式

5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole

sodium cyanide

→

(2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile

収率 78.6%

溶媒

dimethylsulfoxide

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction mixture was poured into ice
2. 2
   抽出extracted with ethyl acetate (300 mL)
3. 3
   乾燥The organic layer was dried over sodium sulfate
4. 4
   その他evaporated to dryness

実験手順

A mixture of crude 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole (4.4 g) and sodium cyanide (1.36 g, 27.8 mmol) in dimethylsulfoxide (50 mL) was stirred at room temperature overnight. The reaction mixture was poured into ice and extracted with ethyl acetate (300 mL). The organic layer was dried over sodium sulfate and evaporated to dryness to give crude (2,2-difluoro-benzo[1,3]dioxol-5-yl)-acetonitrile (3.3 g) which was used directly in the next step.

出典