反応 #46173

反応方程式

6-Bromomethyl-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester

Pyridine

morpholine

→

6-(morpholine-4-yl methyl)-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester

収率 16.1%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the organic layer was extracted with ethyl acetate/ammonium chloride/saturated sodium chloride
2. 2
   乾燥dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated
4. 4
   その他the resulting residue was purified by column chromatography

実験手順

6-Bromomethyl-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester (1.1 g, 2.96 mmol) was dissolved in N,N-dimethylformamide. Pyridine (264 μl, 3.26 mmol) and morpholine (284 μl, 3.26 mmol) were added thereto and the mixture was stirred for 2 hours. After the reaction was completed, the organic layer was extracted with ethyl acetate/ammonium chloride/saturated sodium chloride, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 180 mg of 6-(morpholine-4-yl methyl)-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester (180 mg, yield 16.1%) as red oil.

出典