反応 #46169

反応方程式

Sodium hydride

diethyl carbonate

3-methylacetophenone

→

3-oxo-3-m-tolylpropionate ethyl ester

収率 84.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   抽出Then, the mixture was extracted with ethyl acetate/saturated sodium chloride
2. 2
   乾燥The extract was dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated
4. 4
   その他the resulting residue was purified by column chromatography

実験手順

Sodium hydride (3.1 g, 77.1 mmol) and diethyl carbonate were combined with 3-methylacetophenone (4.5 g, 33.54 mmol). The mixture was stirred for 2 hours at 80° C. After the reaction was completed, ice water and acetic acid were added thereto. Then, the mixture was extracted with ethyl acetate/saturated sodium chloride. The extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 3-oxo-3-m-tolylpropionate ethyl ester (5.8 g, yield 84%).

出典