反応 #46157

反応方程式

Piperonyl alcohol

Triethylamine

thionyl chloride

→

5-chloromethyl benzo[1,3]dioxol

収率 100.0%

溶媒

benzene

反応条件

後処理

1. 1
   抽出The reaction mixture was extracted with sodium bicarbonate and ethyl acetate
2. 2
   その他the organic layer was separated
3. 3
   乾燥dried over anhydrous magnesium sulfate

実験手順

Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).

出典