反応 #46126

反応方程式

Potassium permanganate

2-fluoro-5-methylbenzenesulphonamide

2-fluoro-5-methylaniline

NaOH

→

title product

4-fluoro-3-sulphamoylbenzoic acid

溶媒

water

反応条件

後処理

1. 1
   その他obtained
2. 2
   workup.DISSOLUTIONhas completely dissolved
3. 3
   ろ過the suspension is discharged by filtration in the hot state
4. 4
   workup.ADDITIONby adding 12N HCl
5. 5
   その他The precipitate obtained
6. 6
   ろ過is collected by filtration
7. 7
   洗浄washed with water
8. 8
   その他dried

実験手順

A suspension of 2-fluoro-5-methylbenzenesulphonamide (5.3 mmol), obtained according to the process described in Step A of Example 1 starting from 2-fluoro-5-methylaniline, in water (50 mL) is heated at 70° C. and then NaOH 10% w/v is added dropwise until the compound has completely dissolved. Potassium permanganate (3 g) is added in small portions. After stirring for 4 hours, the suspension is discharged by filtration in the hot state and the filtrate is brought to pH 1 by adding 12N HCl. The precipitate obtained is collected by filtration, washed with water and dried to yield the title product in the form of a white solid.

出典