反応 #46123

反応方程式

7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide

potassium carbonate

cyclopropylmethyl bromide

→

7-chloro-4-cyclopropylmethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度the mixture is heated
2. 2
   温度at reflux for 24 hours
3. 3
   その他The reaction mixture is evaporated under reduced pressure
4. 4
   ろ過The insoluble material is collected by filtration
5. 5
   洗浄washed with water
6. 6
   その他dried
7. 7
   その他is recrystallised from methanol

実験手順

To a solution of 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (1 g) in acetonitrile (40 mL) there is added potassium carbonate (2.5 g) and cyclopropylmethyl bromide (0.7 mL) and the mixture is heated at reflux for 24 hours. The reaction mixture is evaporated under reduced pressure and the residue is taken up in water (40 mL). The insoluble material is collected by filtration, washed with water and dried and is recrystallised from methanol.

出典