反応 #46116

反応方程式

2-Chloro-5-nitrobenzenesulphonamide

cyclopropylamine

→

2-cyclopropylamino-5-nitrobenzenesulphonamide

溶媒

dioxane

反応条件

後処理

1. 1
   workup.ADDITIONabove is introduced into a hermetically closed vessel
2. 2
   workup.ADDITIONcontaining
3. 3
   その他After this time period, the solvent and the reagent are removed
4. 4
   濃縮by concentrating under reduced pressure
5. 5
   ろ過is collected by filtration
6. 6
   洗浄washed with methanol
7. 7
   その他dried

実験手順

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

出典